Mechanically-induced osteogenesis in the cortical bone of pre- to peripubertal stage and peri- to postpubertal stage mice

Mechanically-induced osteogenesis in the cortical bone of pre- to peripubertal stage and peri- to postpubertal stage mice

Blog Article

Abstract Background Exercise during postnatal development plays a key role in determining adult bone mass and reducing the risk of fracture and osteoporosis later in life.However, the relationship between mechanically-induced osteogenesis and age is unclear.Elevated levels of estrogen during puberty may inhibit periosteal bone formation.Thus, magnitudes of 2005 honda accord intake manifold mechanically-induced osteogenesis may be vary with pubertal state.Methods The present study uses a murine model to examine age-related changes in bone formation at the femoral midshaft with voluntary exercise.

Pre- to peripubertal mice aged 3 weeks and peri- to postpubertal mice aged 7 weeks were randomly divided into sedentary and exercised groups and subjected to histomorphometric comparison after 4 weeks of treatment.Results Results of the experiment indicate that exercise significantly increased osteogenesis on the periosteal and endocortical surface of the mice in the older age group (P P Conclusion These findings suggest that the amount and location of tonic shower cap mechanically-induced osteogenesis differs by age during skeletal development.Late adolescence may be the optimal time to accrue bone mass and maximize bone strength.